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What is Dapoxetine?

Dapoxetine is an extremely short acting SSRI which is used for the treatment of premature ejaculation in men. It is the only drug which has been approved for this use, but currently that approval has only been gained in a handful of European countries, including Germany, Italy and Portugal. It is currently awaiting assessment in other European countries and in the US. Other SSRIs have been used for treatment of premature ejaculation in the past but they have been unsuitable because most of them take days to reach peak plasma level. Dapoxetine, because of its rapid absorption will begin to be effective within sixty minutes, making it suitable to be taken as required. Dapoxetine was originally developed by Eli Lilly and company as an antidepressant before being sold to Johnson and Johnson who submitted it to the FDA for approval in 2004.

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Dapoxetine in the boxHow does Dapoxetine work?

Because dapoxetine has a much shorter half-life than other SSRIs, it quickly clears from the body, allowing normal emotional and mental functioning. Dapoxetine is cleared from the body within hours, as compared to days with other antidepressants. Dapoxetine is rapidly absorbed and will begin to take effect within sixty minutes. Peak plasma concentration occurs between 85 and 120 minutes and the effect will usually last between two and four hours.

How effective is dapoxetine for premature ejaculation?

Some studies have shown that dapoxetine can provide significantly prolonged sexual intercourse for men with moderate or severe premature ejaculation. However, like all SSRIs, dapoxetine users run the risk of rare but potentially dangerous side effects. These include suicidal ideation and an increase in violent behavior among long-term SSRI users. Dapoxetine has yet to undergo extensive clinical trials, but some experts express considerable doubt as to whether the effectiveness of the drug for some men outweighs the attendant risks. To date the US Food and Drugs Administration has declined to clear dapoxetine for sale because it is not convinced of the positive effect. Two clinical trials involving a total of 2,614 men with an average time of one minute from penetration to ejaculation, showed an average time of 2.78 minutes after taking 30 mg of Dapoxetine and an average time of 3.32 minutes after taking 60 mg of Dapoxetine.

What does Dapoxetine look like?

Dapoxetine is available as a round blue tablet in strengths of 30 or 60 mg with the strength in milligrams imprinted.

Dapoxetine dosing and administration

The usual starting dosage of Dapoxetine is 30 mg in a single dose taken an hour before sex is planned. If this dose is inadequate, your doctor may incrementally increase the dosage up to a maximum of 60 mg until the desired effect is obtained.

Common adverse effects from Dapoxetine

Dapoxetine may cause the same range of side effects as all SSRIs however, because it is effective for premature ejaculation at relatively low dosages, these side effects are rarely serious. As with all SSRIs any symptoms of serotonin syndrome should be reported to your doctor immediately.

What is Meridia?

Meridia is a trade name used by Abbott Laboratories for Sibutramine, an appetite suppressant used in the treatment of obesity caused by overeating. The drug was originally marketed by Knoll Pharmaceuticals. Although successful in promoting weight loss in conjunction with a low-calorie diet and exercise, it has been associated with an increased risk of heart attack and cerebrovascular incident and was withdrawn in late 2010 from a number of major markets, including the US, the UK , the European Union, China, Australia, Canada and India. Continue reading Meridia Obesity Treatment Medication

What is Lasix?

Lasix is the brand name of Sanofi-Aventis for the diuretic furosemide. This loop diuretic is used mainly in the treatment of high blood pressure and edema. It is commonly used to combat fluid retention caused by congestive heart failure, cirrhosis and kidney failure.

How does Lasix work?
Lasix bottle

Lasix works by increasing the amount of salt and water removed from the blood by the kidneys and excreted in the urine. This causes a decrease in overall blood volume which in turn lowers blood pressure.

What does Lasix look like?

Lasix is presented as an elliptical white tablet of 20 mg strength and round white tablets of 40 and 80 mg strength. Continue reading Lasix – congestive heart failure, liver disease, or kidney disorder medicine

What is Inderal?

Inderal is Wyeth Pharmaceutical’s trade name for propranolol, the first successful beta-blocker, which was developed by James W. Black in the 1960s and for which he won the Nobel Prize. Earlier attempts to develop effective beta-blockers had run into problems with carcinogenicity and Black successfully eliminated this problem while at the same time increasing the potency of the drug. It is used to treat tremors, angina pectoris, hypertension, arrhythmia and other cardiovascular conditions. It is also used for the treatment and prevention of heart attack and to reduce the severity of migraine headaches.

Indreal in a boxHow does Inderal work?

As a non-selective beta-blocker, Inderal inhibits both epinephrine and norepinephrine by blocking adrenergic receptors. It also inhibits the norepinephrine transporter and stimulates norepinephrine release. Continue reading Inderal – Beta Blocker for Cardiovascular Diseases

What is Ismo?

Ismo is a trade name for isosorbide mononitrate, a vasodilator used to treat angina pectoris due to coronary artery disease as a prophylactic treatment. It is not sufficiently fast acting to stop an acute episode of angina. It has also been used as a cervical dilator to speed delivery in obstetric hospitals

ismoHow does Ismo work?

Like all nitrates, Ismo works by dilating blood vessels to reduce the workload on the heart.

What does Ismo look like?

Ismo is supplied as a round orange pill with a strength of 20 mg and imprinted with “Ismo 20 W”. Continue reading Ismo – angina pectoris treatment drug

What is Ativan?

Ativan is a brand name used by Biovail Pharmaceuticals for lorazepam. This is one of the longest-acting benzodiazepines and is used orally as an anxiolytic and by injection to treat nervous tension and seizures. Ativan is highly addictive and so, if used for sleep induction, should be only used in the short term. It is useful in the sedation of hospital patients and aggressive individuals. Because of its strong amnesic properties it has been widely exploited for criminal purposes, particularly sexual assault.

ativanHow does Ativan work?

Like all benzodiazepines, Ativan works by enhancing the effects of GABA. It is a classic benzodiazepine which acts at benzodiazepine sites on GABA receptors throughout the central nervous system. Ativan has strong affinity for GABA receptors which is believed to be the reason for its potent amnesic effect. Continue reading Anxiety disorder treatment drug – Ativan